ISAAC REBIRTH THE LOST FULL

One Globin is always alive at a time and attacking The Lost. The Lost fights Globins, while his follower is not doing enough damage to finish them off after they fell into goo.Familiars like Leech are useless, while The Lost is constantly attacked by a Mask.

ISAAC REBIRTH THE LOST FULL

The Lost fights a room full of Mask + Heart, the Hearts being behind a pit.

Poky pushes constantly against The Lost, forcing him not to move. The boss will always stay at distance, making familiars like Distant Admiration useless.

The Lost fights Loki with a Poky inside the room.

The Virus: Similar to Midas' Touch, enemies that touch The Lost when Gnawed Leaf is active will be poisoned, but is useless against foes and bosses who stay away from The Lost.ДЄlthough the strategy is quite safe, game-ending issues likely occur.

Still has trouble with large rooms, however.

Succubus: Similar to The Peeper, but with a much larger area of effect.

The flies may not attack foes far away, the spiders are unable to pass over pits.

Rotten Baby and Sissy Longlegs: Blue Flies and Spiders target most enemies inside a room.

If Robo-Baby 2.0 is moved, a statue form will be exited. Robo-Baby 2.0 will still clear most rooms.

Robo-Baby 2.0: Shoots only horizontal and vertical, not reaching enemies that stay diagonally.

The Peeper: It reaches any spot of a room and will be able to take out most enemies.

Orbitals: Provide decent damage against chasing enemies, but are useless against enemies that stay on distance.

Midas' Touch: Still dealing damages when Gnawed Leaf is active, maybe useless against bosses who stay away from The Lost.

Lil Haunt: While not as powerful as Daddy Longlegs, it's one of the few familiars that chase enemies (and don't require you to take damage to summon).

Leech: Can chase after enemies like Lil Haunt, but due to its poor programming, it often gets stuck, causing you to have to move to kill an enemy.

Demon Baby and Gemini: Reliably take out enemies nearby, but will not target foes far away.

Daddy Longlegs: Extremely powerful, because it reaches any enemy and will eventually clear the room against any type of hostiles.

The War and Death harbingers will also chase enemies.

7 Seals: Extremely powerful, as the harbingers will travel anywhere across a room while spawning locusts and leaving trails of creep.

This strategy requires a lot of patience.ДЄlthough many familiars are not able to clear all types of enemies or rooms, it is still recommended to get any type of familiar the player finds. There are almost no rooms where The Lost gets hit before it enters statue form. This allows The Lost to enter a room, become invulnerable, and let its familiar clear the room. It combines Gnawed Leaf with any automatically damaging familiar. This strategy is very safe and easily played. The only exception is possessing some source of shield (e.g.

The Lost must never use a Blood Donation Machine or a Devil Beggar as Holy mantle effect won't protect him in this case, resulting in immediate death.

Since The Lost does not take damage from the Greed Mode button, you can dramatically limit the number of enemies you have to face at a given time by stepping back onto the button after activating it.

With the Missing Poster, a run may be taken to the end with an easier character and finished as The Lost by dying on purpose, granting the unlock for The Lost without doing a full run.This makes pills more useful since they are more likely to have positive effects. The Lost does not receive Bad Trip or Health Down pills.

It is recommended to use Slot Machines as much as possible to obtain Pretty Flies.

Three orbitals of any kind absorb nearly all projectiles.

If an option to reroll items is found, they can be changed if not yet picked up.

The same applies to useless items (except while holding the D4, that can reroll the passive items).

It is recommended to avoid picking them up in case the D20, a Dice Room (with 3 pips, 2 if the hearts spawn in the Dice Room), or a Dice Shard is found later on.

The Lost will absorb soul, black, and Eternal Hearts by picking them up, but will not gain any health from them.

Bombs can be used to escape rooms you think you cannot handle.

If the player manages to get good item combinations, the difficulty will not matter much.

Always play on hard mode, as hard mode is required to unlock Godhead.

The Lost's ability to fly can be used to hide safely above obstacles and pits, avoiding enemies and projectile contact.

It is recommended to have advanced knowledge of all types of rooms, champions, and enemies.

This can be done by donating 879 to the Greed Machine.

It is absolutely suggested to unlock The Lost's intrinsic Holy Mantle greatly lowering the difficulty of his usage.

Before attempting runs with The Lost, unlock any items that may be helpful for The Lost.

Isaac rebirth the lost